Accurate particle size analysis is crucial in research, development, and manufacturing across a wide range of industries. From pharmaceuticals to paints and coatings, particle size affects key properties such as dissolution rate, stability, color, texture, and flowability. Selecting the correct sizing technique ensures not only product quality but also compliance with regulatory requirements.

When choosing a particle sizing technique, start by defining your goals. What do you want to achieve? Whether it’s detecting agglomerates or controlling the fine particle fraction, your objectives will guide you to the right techniques with the necessary sensitivities.

Even if you’re limited by the techniques available, understanding their strengths and weaknesses ensures you get realistic and robust results. Key factors to consider include the size range the instrument can measure, the types of samples it can handle (dry powders, suspensions, emulsions, and sprays), and the technique’s sensitivity (number or volume-based). Also, think about the accuracy and precision you can expect.

Practical considerations are just as important. How many measurements do you need to perform each day? How long will each measurement take? How much sample dilution is required? And do you need additional information, like particle shape?

This guide explores the most widely used particle sizing methods and offers insight into how to select the best approach for your materials and objectives.